Beyond Bioinformatics
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Beyond Bioinformatics |
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Title |
A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culex species from diverse geographical locations
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Authors |
Ryavarapu Bhargavi1, Siddharth Vishwakarma2 and Upadhyayula Suryanarayana Murty1*
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Affiliation |
1Bioinformatics Group, Biology Division, Indian Institute of Chemical Technology, Hyderabad, India; 2Department of P.G. Studies and Research in Biological Sciences, RDVV, Jabalpur, India.
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E-mail* |
murty_usn @yahoo.com; * Corresponding author
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Fax |
+91-40-27193227
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Article Type |
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Hypothesis
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Date |
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received August 15, 2005; revised September 19, 2005; accepted October 3, 2005; published online October 5, 2005
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In the present study, sequence and structural analysis of ITS2 region (the spacer segment between 5.8S and 28S rRNA of mature rRNA sequences) of 7 Culex species belonging to 5 different geographical locations was carried out. Alignment of the ITS2 sequence from the 7 species revealed 8 homologous domains. Four species namely C. vishnui, C. annulus, C. pipiens, C. quiquefasciatus showed high sequence (98-100%) and RNA secondary structure similarity. The ITS2 similarity among different species is high despite their varying geographical locations. Several common features of secondary structure are shared among these species, with some of them supported by compensatory changes, suggesting the significant role by ITS2 as an RNA domain during ribosome biogenesis. |
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Keywords |
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Culex; ITS2; secondary structure; geographical locations; ribosome biogenesis
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Citation |
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Bhargavi et al., Bioinformation 1(2): 52-55 (2005)
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Edited by |
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Paul Shapshak
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ISSN |
0973-2063
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Publisher |
Biomedical Informatics Publishing Group
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Copyright |
Publisher
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Copyright Transfer Agreement |
The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.
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License |
This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited for non-commercial purposes.
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