Beyond Bioinformatics

Title

Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum

Authors

Venkata Rao Dodaghatta Krishna Rao^1*, Rallapalli Ramanjeneyulu¹, Dowlathabad Muralidhara Rao^2* and Chitta Suresh Kumar³

Affiliation

¹Department of Microbiology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India; ²Department of Biotechnology, Bioinformatics Laboratory, Sri Krishnadevaraya University, Anantapur; ³Department of Biochemistry, Sri Krishnadevaraya University, Anantapur.

E-mail*

muralidhararao@yahoo.co.in; * Corresponding author

Article Type

Views & Proposal

Date

received December 28, 2005; revised January 23, 2006; accepted January 24, 2006; published online January 24, 2006

Lysyl tRNA synthetases facilitate amino acylation and play a crucial role in the essential cellular process of translation. They are grouped into two distinct classes (class I and class II). Class I lysyl tRNA synthetase is considered as a drug target for syphilis caused by Treponema pallidum. Comparative genome analysis shows the absence of its sequence homolog in eukaryotes. The structure of class I lysyl tRNA synthetase from Treponema pallidum is unknown and the difficulties in the in vitro culturing of Treponema makes it non-trivial. We used the structural template of class I lysyl tRNA synthetase from the archaea Pyrococcus horikoshii for modeling the Treponema pallidum lysyl tRNA synthetase structure. Thus, we propose the usefulness of the modeled class I lysyl tRNA synthetase for the design of suitable inhibitors towards the treatment of syphilis.

Keywords

Treponema pallidum; lysyl tRNA synthetase; modeller; syphilis; comparative modeling

Citation

Rao et al., Bioinformation 1(3): 81-82, (2006)

Edited by

N. Gautham

ISSN

0973-2063

Publisher

Biomedical Informatics Publishing Group

Copyright

Publisher

Copyright Transfer Agreement

The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.

License

This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.