Beyond Bioinformatics

Title

Matrix protein 1: A comparative in silico study on different strains of influenza A H5N1 Virus

Authors

Tamanna Anwar ¹, Sunil K Lal ³ and Asad U Khan  ^{1, 2*}

Affiliation

¹Distributed Information Sub-centre; ²Interdisciplinary Biotechnology Unit Aligarh Muslim University, Aligarh 202002 India; ³International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110 067, India

Email

huzzi99@hotmail.com; * Corresponding author

Article Type

Prediction Model

Date

received November 13, 2006; accepted November 21, 2006; published online November 22, 2006

Abstract

The importance of influenza viruses as worldwide infectious agents is well recognized. Specific mutations and evolution in influenza viruses is difficult to predict. We studied specific mutations in matrix protein 1 (M1) of H5N1 influenza A virus together with properties associated with it using prediction tools developed in Bioinformatics. Changes in hydrophobicity, polarity and secondary structure at the site of mutation were noticed and documented to gain insight towards its infection.

Keywords

matrix protein 1 (M1); mutation; N-myristoylation site

Citation

Edited by

P. Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics Publishing Group

Copyright

Publisher

Copyright Transfer Statement

The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.

License

This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.