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Title

 

 

 

 

Matrix protein 1: A comparative in silico study on different strains of influenza A H5N1 Virus

 

Authors

Tamanna Anwar 1, Sunil K Lal 3 and Asad U Khan  1, 2*

 

Affiliation

1Distributed Information Sub-centre; 2Interdisciplinary Biotechnology Unit Aligarh Muslim University, Aligarh 202002 India; 3International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110 067, India

 

Email

huzzi99@hotmail.com; * Corresponding author

 

Article Type

Prediction Model

 

Date

received November 13, 2006; accepted November 21, 2006; published online November 22, 2006

 

Abstract

The importance of influenza viruses as worldwide infectious agents is well recognized. Specific mutations and evolution in influenza viruses is difficult to predict. We studied specific mutations in matrix protein 1 (M1) of H5N1 influenza A virus together with properties associated with it using prediction tools developed in Bioinformatics. Changes in hydrophobicity, polarity and secondary structure at the site of mutation were noticed and documented to gain insight towards its infection.

 

Keywords

 

matrix protein 1 (M1); mutation; N-myristoylation site

Citation

Anwar et al., Bioinformation 1(7): 253-256 (2006)

 

Edited by

P. Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.