Title

Is there an alternative to increasing the sample size in microarray studies?

Authors

Lev Klebanov^{1, 2} and Andrei Yakovlev^2*

Affiliation

¹Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Box 630, Rochester, New York 14642; ²Department of Probability and Statistics, Charles University, and Institute of Informatics and Control of the National Academy of Sciences, Sokolovska 83, Praha-8, CZ-18675, Czech Republic

Email

Andrei_Yakovlev@URMC.Rochester.edu; * Corresponding author

Article Type

Views & Challenges

Date

      received October 05, 2006; accepted January 29, 2007; published online April 10, 2007

Abstract

Our answer to the question posed in the title is negative. This intentionally provocative note discusses the issue of sample size in microarray studies from several angles. We suggest that the current view of microarrays as no more than a screening tool be changed and small sample studies no longer be considered appropriate.

Keywords

sample size; microarray; alternative

Citation

Klebanov & Yakovlev, Bioinformation 1(10): 429-431 (2007)

Edited by

Susmita Datta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.