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Beyond Bioinformatics | |
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Title |
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On the challenges of the HapMap resource
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Authors |
Wei Zhang1 and M. Eileen Dolan1, 2, 3
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Affiliation |
1Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA; 2Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA; 3Cancer Research Center, University of Chicago, Chicago, IL 60637, USA
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edolan@medicine.bsd.uchicago.edu
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+773-702-4441
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| Fax |
+773-702-0963; * Corresponding author
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Article Type |
Views & Challenges
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Date |
received December 29, 2007; accepted January 09, 2008; published January 11, 2008
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| Abstract |
The International HapMap Project provides a key resource of genotypic data on human lymphoblastoid cell lines derived from four major world populations of European, African, Chinese and Japanese ancestry for researchers to associate with various phenotypic data to find genes affecting health, disease and response to drugs. Recently, the HapMap resource has significantly benefited research areas such as gene expression variation studies. Besides some intrinsic limitations, there are a few challenges that should be considered in the next wave of research using this tremendous resource. We suggest that overcoming these challenges or considering the confounding variables in the interpretation of results can provide more insights into the current views of the human genome as well as complex traits such as drug response variation and susceptibility to common diseases.
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| Keywords |
HapMap; lymphoblastoid cell lines; single nuceotide polymorphism; genotype; gene expression
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Citation |
Zhang and Dolan, Bioinformation 2(6): 238-239 (2008)
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Edited by |
P. Kangueane
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ISSN |
0973-2063
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Publisher |
Biomedical Informatics Publishing Group
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Copyright |
Publisher
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Copyright Transfer Agreement |
The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.
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License |
This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
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