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Title
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Towards the interaction mechanism of tocopherols and tocotrienols (vitamin E) with selected metabolizing enzymes
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Authors
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Jyoti Upadhyay and Krishna Misra | |
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Affiliation
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Indian Institute of Information Technology, Allahabad - 211 002; India | |
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Article Type
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Hypothesis | |
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Date
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received October 15, 2008; revised November 22, 2008; accepted December 01, 2008; published April 21, 2009
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Abstract |
Vitamin E is a mixture of eight compounds α, β, γ, δ- tocopherols and α, β, γ, δ- tocotrienols. Their individual role in cellular transport as antioxidants and in metabolic pathways has been highlighted in the present work. All the eight compounds have been docked with the respective metabolizing enzymes (α-tocopherol transfer protein (ATTP), α-tocopherol associated protein (TAP), P-glycoprotein (P-gly) and human serum albumin (HSA)) to understand molecular interactions for pharmacokinetics. These have been structurally aligned against the four human phospholipids in order to reveal their individual role in chylomicron formation and hence the mechanism of cellular transport. The study of their binding with their metabolizing enzymes provides insight to the comparative antioxidant activity of each of these isomers.
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Keywords |
docking data; vitamin E, enzymes, mechanism; anti-oxidant
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Citation |
Upadhyay & Misra, Bioinformation 3(8): 326-331 (2009)
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Edited by |
P. Kangueane
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ISSN |
0973-2063
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Publisher |
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Copyright |
Publisher
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Copyright Transfer Agreement
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The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.
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License
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This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
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