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Title |
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Abyssinones and related flavonoids as potential steroidogenesis modulators
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Authors |
Kaushik S. Hatti, Latha Diwakar, G. Venkateswara Rao, Anil Kush, G. Chandrasekara Reddy*
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Affiliation |
Vittal Mallya Scientific Research Foundation, PB No 406, K.R. Road; Bangalore 560004, India
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Article Type
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hypothesis | |
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Date
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received February 19, 2009; revised April 8, 2009; accepted May 11, 2009; published June 28, 2009 | |
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Abstract |
Abyssinones and related flavonoids were screened against 3 enzymes (3βHSD, 17βHSD and Aromatase) of steroidogenesis pathway. The virtual screening experiment shows high affinity for flavonones than their respective chalcones. A 4’ –OH blocked prenylated flavonone 2b (2-(2’, 2’-dimethyl chroman-6’-yl)-7-hydroxy chroman-4-one) had consistent binding affinity to all the three enzymes used in this study showing higher binding affinity to aromatase. A good correlation was observed between cytotoxic data (MCF-7, breast cancer cell line) and docking results indicating flavonone as a better steroidogenesis modulator in hormone dependent cancer.
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Keywords |
flavonoids; steoidogenesis modulators; docking; model; cancer | |
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Citation |
Hatti et al, Bioinformation 3(9): 399-402 (2009) | |
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Edited by |
P. Kangueane
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ISSN |
0973-2063
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Publisher |
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Copyright |
Publisher
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Copyright Transfer Agreement
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The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.
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License
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This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
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