Title

Phylogenetic analysis of surface proteins of novel H1N1 virus isolated from 2009 pandemic

Authors

Mohd Danishuddin¹, Shahper N Khan¹, Asad U Khan^1,*

Affiliation

¹Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh-202002, India

Email

asad.k@rediffmail.com

Article Type

Hypothesis

Date

Received July 07, 2009; Revised July 27, 2009; Accepted August 18, 2009; Published September 30, 2009

Abstract

Swine Influenza Virus (H1N1) is a known causative agent of swine flu. Transmission of Swine Influenza Virus form pig to human is not a common event and may not always cause human influenza. The 2009 outbreak by subtype H1N1 in humans is due to transfer of Swine Influenza Virus from pig to human. Thus to analyze the origin of this novel virus we compared two surface proteins (HA and NA) with influenza viruses of swine, avian and humans isolates recovered from 1918 to 2008 outbreaks. Phylogenetic analyses of hemagglutinin gene from 2009 pandemic found to be clustered with swine influenza virus (H1N2) circulated in U.S.A during the 1999-2004 outbreaks. Whereas, neuraminidase gene was clustered with H1N1 strains isolated from Europe and Asia during 1992-2007 outbreaks. This study concludes that the new H1N1 strain appeared in 2009 outbreak with high pathogenicity to human was originated as result of re-assortment (exchange of gene). Moreover, our data also suggest that the virus will remain sensitive to the pre-existing therapeutic strategies.
 

Citation

Danishuddin et al., Bioinformation 4(3): 94-97 (2009)

Edited by

P. Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.