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Title

 

 

 

 

 

Computational Epigenetics: the new scientific paradigm

Authors

 

Shen Jean Lim1, Tin Wee Tan1, Joo Chuan Tong1,2,*

Affiliation

 

1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597;2Data Mining Department, Institute for Infocomm Research, 1 Fusionopolis Way, #21-01, Connexis, South Tower, Singapore 138632

 

Email

 

jctong@i2r.a-star.edu.sg

Article Type

 

Current Trends

Date

 

Received December 15, 2009; Revised January 13, 2009; Accepted January 21, 2009; Published January 23, 2010

 

Abstract

Epigenetics has recently emerged as a critical field for studying how non-gene factors can influence the traits and functions of an organism. At the core of this new wave of research is the use of computational tools that play critical roles not only in directing the selection of key experiments, but also in formulating new testable hypotheses through detailed analysis of complex genomic information that is not achievable using traditional approaches alone. Epigenomics, which combines traditional genomics with computer science, mathematics, chemistry, biochemistry and proteomics for the large-scale analysis of heritable changes in phenotype, gene function or gene expression that are not dependent on gene sequence, offers new opportunities to further our understanding of transcriptional regulation, nuclear organization, development and disease. This article examines existing computational strategies for the study of epigenetic factors. The most important databases and bioinformatic tools in this rapidly growing field have been reviewed.

 

Keywords

epigenetic informatics, epigenetics, epigenomics, bioinformatics

Citation

 

Lim et al., Bioinformation, 4 (7) 331-337 (2010)

Edited by

 

P. Kangueane

 

ISSN

 

0973-2063

 

Publisher

 

Biomedical Informatics

Copyright

 

Publisher

 

Copyright Transfer Agreement

 

The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.

 

License

 

 

This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.