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Title
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Discriminating antigen and non-antigen using proteome dissimilarity: bacterial antigens.
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Authors
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Kamna Ramakrishnan1, Darren R Flower 2,* | |
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Affiliation
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The Jenner Institute, University of Oxford, Compton, Newbury, Berkshire, United Kingdom, RG20 7NN; 1Medical Genetics Section, University of Edinburgh, Edinburgh, United Kingdom. EH4 2XU; 2Life and Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom. B5 7ET.
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Article Type
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Hypothesis | |
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Date
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Received March 19, 2010; accepted April 14, 2010; published April 30, 2010 | |
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Abstract |
It has been postulated that immunogenicity results from the overall dissimilarity of pathogenic proteins versus the host proteome. We have sought to use this concept to discriminate between antigens and non-antigens of bacterial origin. Sets of 100 known antigenic and nonantigenic peptide sequences from bacteria were compared to human and mouse proteomes. Both antigenic and non-antigenic sequences lacked human or mouse homologues. Observed distributions were compared using the non-parametric Mann-Whitney test. The statistical null hypothesis was accepted, indicating that antigen and non-antigens did not differ significantly. Likewise, we were unable to determine a threshold able to separate meaningfully antigen from non-antigen. Thus, antigens cannot be predicted from pathogen genomes based solely on their dissimilarity to the human genome.
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Keywords |
antigen, non-antigen, proteome, dissimilarity, bacterial antigens
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Citation
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Ramakrishnan et al. Bioinformation 4(10): 000-000 (2010)
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Edited by
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P. Reche
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ISSN
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0973-2063
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Publisher
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Copyright
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Publisher
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Copyright Transfer Agreement
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The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.
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License
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This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited. |