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Title

Computational analysis of human and mouse CREB3L4 Protein

 

Authors

Kiran Kumar Velpula1, Azeem Abdul Rehman2, Soumya Chigurupati1, Ramadevi Sanam3, Krishna Kishore Inampudi4 & Chandra Sekhar Akila5*

 

Affiliation

1Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Blvd, Orlando, FL 32816; 2Bradley University, Peoria, IL, 61615; 3Informatics Division, GVK Biosciences Pvt Ltd, Hyderabad, India; 4Department of Chemistry, University of Hyderabad, India 500046; 5Department of Biotechnology, School of Life Sciences, Yogi Vemana University, Kadapa, Andhra Pradesh, India -516003

 

Email

chandrasekhar9@yahoo.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received June 05, 2012; Accepted June 08, 2012; Published June 28, 2012

Abstract

CREB3L4 is a member of the CREB/ATF transcription factor family, characterized by their regulation of gene expression through the cAMP-responsive element. Previous studies identified this protein in mice and humans. Whereas CREB3L4 in mice (referred to as Tisp40) is found in the testes and functions in spermatogenesis, human CREB3L4 is primarily detected in the prostate and has been implicated in cancer. We conducted computational analyses to compare the structural homology between murine Tisp40α human CREB3L4. Our results reveal that the primary and secondary structures of the two proteins contain high similarity. Additionally, predicted helical transmembrane structure reveals that the proteins likely have similar structure and function. This study offers preliminary findings that support the translation of mouse Tisp40α findings into human models, based on structural homology.

 

Citation

Velpula et al. Bioinformation 8(12): 574-577 (2012)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.