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Title

Gene interaction studies in cellular reprogramming of adult stem cells to embyronic like stem cells

 

Authors

Nishanthi Gangadaran1 & Jannet Vennila James2*

 

Affiliation

1Department of Bioinformatics, School of Biotechnology & Health Sciences, Karunya University, Coimbatore 641114, South India; 2Department of Bioinformatics, School of Biotechnology, & Health Sciences Karunya University, Coimbatore 641114, South India

 

Email

jannet_r@karunya.edu; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received September 07, 2012; Accepted September 12, 2012; Published October 01, 2012

Abstract

The sophisticated process of reprogramming of adult stem cells to embryonic-like stem cells, known as cellular reprogramming, involves the risk of generation of tumorigenic cells due to the complexity involved. Oct4 protein is the inevitable element for inducing pluripotency along with Sox2 and Nanog proteins. In this study, the set of genes interacting with Oct4, Sox2 and Nanog were analyzed and categorized based on their molecular function. Later, the domains of translated products of 46 transcription factors interacting with Oct4, Sox2 and Nanog were identified, clustered them based on the nature of the domain and multiple sequence alignment was performed to find any functionally important consensus regions in the sequence. The key finding of this study is the 13 member cluster of homeo domain transcription factors exhibited some consensus in their sequence.

 

Citation

Gangadaran & James, Bioinformation 8(19): 912-915 (2012)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.