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Title |
Molecular screening of phytochemicals from Amelanchier Alnifolia against HCV NS3 protease/helicase using computational docking techniques |
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Authors |
Mahim Khan, Muhammad Shareef Masoud, Muhammad Qasim, Muhammad Asaf Khan, Muhammad Zubair, Sobia Idrees, Asma Ashraf & Usman Ali Ashfaq*
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Affiliation |
Department of Bioinformatics and Biotechnology, Government College University (GCU), Faisalabad, Pakistan |
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usmancemb@gmail.com; *Corresponding author |
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Article Type |
Hypothesis |
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Date |
Received August 01, 2013; Revised October 31, 2013; Accepted November 02, 2013; Published December 06, 2013
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Abstract |
Hepatitis C is serious health concern worldwide caused by HCV. It causes liver cirrhosis and hepato-cellular carcinoma. Development of prevention solutions is under progress. Mean while, the treatment of the viral disease using compounds isolated from natural medicinal plants is promising. The traditional use of photo-chemicals from medicinal plants like Amelanchier alnifolia for viral treatment is hopeful. Therefore, it is of interest to screen for flavonoids from Amelanchier alnifolia against protein targets of HCV. Hence, we assessed the binding of flavonoids to HCV NS3/4A protease and helicase proteins. Results show that Quercitin 3-galactoside and 3-glucosideshowed good binding score with protease and helicase respectively. Their interaction/binding sites are documented in this report. This data provide insights for the consideration of flavonoids as potential inhibitors of HCV/NS3/4A protease and helicase. |
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Citation |
Khan et al.
Bioinformation 9(19): 978-982 (2013) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |