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Title

In silico finding of Putative Cis-Acting Elements for the Tethering of Polycomb Repressive Complex2 in Human Genome

 

Authors

Mohammadreza Hajjari1, 2*, Mehrdad Behmanesh2 & Mohammad Mehdi Jahani

 

Affiliation

1Department of Genetics, Shahid Chamran University of Ahvaz, Ahvaz, Iran; 2Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran

 

Email

Mohamad.hajari@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received March 18, 2014; Accepted March 21, 2014; Published April 23, 2014

 

Abstract

Polycomb Repressive Complex2 maintains a predetermined state of transcription which constitutes a cellular memory stable over many cell divisions. Since this complex acts through the regulation of chromatin structure, it is important to understand how it is recruited to chromatin. The specific target sequences of this complex such as PRE (polycomb repressive element) have not been completely recognized in human genome. In this study, we have compared the target sequences of this complex with non-target genes in tumor cell lines. Through in silico and statistical analyses, we have identified some motifs which are over-represented in target genes against non-target genes. Analyzing these motifs shows some transcription factors which are potential recruiters of Polycomb repressive complex2.

 

Keywords

PRC2, SUZ12, Transcription factors, Epigenetics, In silico Analysis

 

Citation

Hajjari et al. Bioinformation 10(4): 187-190 (2014)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.