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Title

Development of tumor lysis syndrome (TLS): A potential risk factor in cancer patients receiving anticancer therapy

 

Authors

Mahmood Rasool1*, Arif Malik2, Muhammad Saeed Qureshi2, Riaz Ahmad2, Abdul Manan2, Muhammad Asif3, Muhammad Imran Naseer1 & Peter Natesan Pushparaj1*

 

Affiliation

1Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia; 2Institute of Molecular Biology and Biotechnology (IMBB), the University of Lahore, Lahore, Pakistan; 3Department of Biotechnology and Informatics, BUITEMS, Quetta, Pakistan

 

Email

mahmoodrasool@yahoo.com; peter.n.pushparaj@gmail.com; *Corresponding authors

 

Article Type

Hypothesis

 

Date

Received May 30, 2014; Revised October 29, 2014; Accepted October 30, 2014; Published November 27, 2014

 

Abstract

Tumor lysis syndrome (TLS) is characterized by hyperuricaemia, hyperphosphatemia, hyperkalaemia, as well as hypocalcaemia due to the breakdown of tumor cells undergoing cancer therapy (chemo/radio). Therefore it is of interest to evaluate oxidative stress using selective biological markers [Malondialdehyde (MDA), Superoxide Dismutase (SOD), Glutathione (GSH) and Catalase (CAT)] in TLS. We report the marked differences (statistically significant with control) observed among a selected set of biomarkers of oxidative stress (MDA = 8.661.37; SOD = 0.150.11; GSH = 2.25.77; CAT = 0.76.57) in TLS patients in addition to other conventional biomarkers. Moreover, correlation was investigated among the parameters of oxidative stress and other circulating biomarkers of TLS. Data suggest the use of SOD, MDA, and GSH as potential diagnostic biomarker for TLS with other biomarkers.

 

Keywords

Tumor lysis syndrome (TLS); hyperuricaemia; hyperphosphatemia; hyperkalaemia; hypocalcaemia; oxidative stress; MDA; SOD; GSH.

 

Citation

Rasool et al. Bioinformation 10(11): 703-707 (2014)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.