Title

Insights from the sequence similarity of Zika virus proteins with the Human nerve proteins

Authors

Prasanna Marsakatla¹, Sujai Suneetha¹, Joshua Lee², Paari Dominic Swaminathan³, Logeshwaran
Vasudevan⁴, Rachael Supriya¹, Lavanya Moses Suneetha¹

Affiliation

¹CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad -500029, Telangana, India;

²York University, Department of Science, 4700 Keele St, Toronto, ON M3J 1P3, Canada;

³LSU Health Sciences Center, Center for Cardiovascular Diseases and Sciences Shreveport, LA, USA; ⁴Presidency College, Department of Zoology, Chennai-05, India;

Email

drlavanyasuneetha@gmail.com

Article Type

Hypothesis

Date

Received April 10, 2018; Revised April 23, 2018; Accepted April 30, 2018; Published May 31, 2018

Massive peptide sharing between the Zika virus polyprotein and host tissue proteins could elicit significant host-pathogen interactions and cross-reactions leading to autoimmune diseases. This study found similarities in the Zika V proteins and human nerve tissue proteins. 63 human nerve proteins were screened for similarities with the Zika V of which Neuromodulin, Nestin, Galanin, Bombesin, Calcium-binding protein were found to have similarities to the Zika V poly protein C at different sequence regions. These sequence similarities could be significant in regulating pathogenic interactions/autoimmunity, as Polyprotein C is known to be a virulent factor.

Keywords

Zika V, Nerve tissue proteins, Neuropathogenesis, Bioinformatics, BLAST, Neuromodulin, Nestin, Bombesin, Galanin, Calcium-binding protein.

Citation

Marsakatla et al. Bioinformation 14(5): 194-200 (2018)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.