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Title |
A review on PIM kinases in tumors
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Authors |
Housna Arrouchi, Wiame Lakhlili*, Azeddine Ibrahimi
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Affiliation |
Laboratory of Biotechnology (MedBiotech), Rabat Medical and Pharmacy School, Mohammed V University in Rabat, Rabat, Morocco
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Wiame Lakhlili – E-mail: wiame.lakhlili@um5s.net.ma; *Corresponding author
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Article Type |
Received December 23, 2018; Accepted January 16, 2019; Published February 3, 2019
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Date |
Review
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Abstract |
The Proviral Integration site for
Moloney murine leukemia virus (PIM) kinases are serine/threonine
kinases that promote growth and survival in multiple cell types,
implicated in the pathogenesis of various diseases. Over expression
of Pim-1 experimentally leads to tumor formation in mice, whereas
there is no observable phenotype concerning the complete knockout of
the protein. When it is over expressed it may lead to cancer
development by three major ways; by inhibiting apoptosis, by
promoting cell proliferation and also through promoting genomic
instability. Expression in normal tissues is nearly undetectable.
Recent improvements in the development of novel inhibitors of PIMs
have been reviewed. Significant progress in the design of PIMs
inhibitors, in which it displays selectivity versus other kinases,
has been achieved within the last years. However, the development of
isoform-selective PIM inhibitors is still an open task. As Pim-1
possesses oncogenic functions and is over expressed in various kinds
of cancer diseases, its inhibition provides a new option in cancer
therapy. A PubMed literature search was performed to review the
currently available data on Pim-1 expression, regulation, and
targets; its implication in different types of cancer and its impact
on prognosis is described. Consequently, designing new inhibitors of
PIMs is now a very active
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Keywords |
Tumor, Pim-1 kinase, Small molecule inhibitors.
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Citation |
Arrouchi et al. Bioinformation 15(1): 40-45 (2019)
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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