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Title

Re-annotation for hypothetical protein CA803_03125 of Methicillin-Resistant Staphylococcus aureus strain SO-1977 isolated from Sudan

 

Authors

Sofia B. Mohamed*, Mohamed M. Hassan, KA Abdalla Munir, Nusiba I. Abdalla, Talal A. Adlan,
Aisha K. Babiker

 

Affiliation

Bioinformatics and Biostatistics Department, National University Research Institute, National University, Sudan

 

Email

Sofia B. Mohamed - Email: Sofiabashir2002@gmail.com; * Corresponding author

 

Article Type

Research Article

 

Date

Received December 12, 2018; Revised December 26, 2018; Accepted December 27, 2018; Published March 15, 2019

 

Abstract

This study aims to describe the global detection and functional inference of hypothetical protein CA803_03125 from Staphylococcus aureus SO-1977. Computational methods were utilized to study this protein based on sequence similarity and presence of known protein domains. The BLASTp result revealed a significant similarity between the hypothetical protein (CA803_03125) and ADP-ribose hydrolase protein from four S. aureus strains (MW2, MRSA252, COL, and N315). Evolutionary tree diagram revealed a close relationship between the hypothetical protein and proteins of MW2 and COL strains. The physicochemical characterization revealed that all proteins were found to be stable, soluble, hydrophilic and acidic in their nature. The Macro domain was found to exist within all proteins. Moreover, the proteins were of pronounced similarity in terms of primary, secondary and tertiary organization. The protein CA803_03125 (SO-1977) is already known and well characterized as ADP-ribose hydrolase; therefore, we would recommend that its NCBI data has to be updated to be submitted under the name of ADP-ribose hydrolase.

 

Keywords

Hypothetical Protein, MRSA SO-1977 strain, Bioinformatics tool, ADP-ribose hydrolase, Sudan

 

Citation

Mohamed et al. Bioinformation 15(3): 160-164 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.