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Effect of salvia Officinalis L. and Rosmarinus Officinalis L. leaves extracts on anxiety and neural



Zineb Choukairi1,*, Tahar Hazzaz1, Mustapha Lkhider1, Josť Manuel Ferrandez2 & Taoufiq Fechtali1



1Laboratory of Biosciences, Functional, integrated and molecular exploration, School Of Sciences and Technology - Mohammedia, Hassan II University of Casablanca; 2Laboratory Of "Inteligencia Ambiental", Polytechnic University of Cartagena, Spain;



Zineb Choukairi - E-mail:; *corresponding author


Article Type

Research Article



Received October 6, 2018; Accepted October 19, 2018; Published March 15, 2019



Anxiety, the illness of our time, is one of the most prevalent and co-morbid psychiatric disorder that represents a significant socioeconomic burden. Conventional treatment is associated with a number of side effects and there is a need to develop new therapeutic strategies. Therefore, it is of interest to investigate the modulating effects of Salvia Officinalis L. and Rosmarinus Officinalis L. leaves extracts on anxiety using different behavioral tests, and on neural activity using the Multi-electrode array technique. Data shows the decrease of the time of the immobility associated with a significant increase in the time spent in the center of the open field arena in the treated animals compared to the controls. The number of buried marbles has also decreased in the treated animals in the marble-burying test. On the other hand results also show a decrease of the neural activity explained by a decrease of the number of spikes after 24,48 and 72 h following the addition of 12,5 μg/ml of the plant leaf extracts to the neural culture. However, there were no spikes after the administration of 25μg/ml of the plants extracts.



Anxiety, Rosmarinus Officinalis L., Salvia Officinalis L., neural activity, GABA.



Choukairi et al. Bioinformation 15(3): 172-178 (2019)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.