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Phylogenetic insight of Nonribosomal peptide synthetases (NRPS) Adenylate domain in Antibacterial potential Streptomyces BDUSMP 02 isolated from Pitchavaram Mangrove



Periyasamy Sivalingam1,2 *, Manickam Muthuselvam2*, John Pote1, Kandasamy Prabakar3



1Department F.A. Forel for Environmental and Aquatic Sciences and Institute of Environmental Sciences, School of Earth and Environmental Sciences, Faculty of Science, University of Geneva, Uni Carl Vogt, 66 Boulevard Carl-Vogt, CH-1211 Geneva 4, Switzerland;2Department of Biotechnology and Genetic Engineering, Bharathidasan University, Tiruchirappalli-620024, Tamil Nadu, India; 3Postgraduate and Research Department of Zoology, Jamal Mohamed College, Tiruchirappalli-620020, Tamil Nadu, India.



Dr. M. Muthuselvam -; *Corresponding author


Article Type

Research Article



Received May 22, 2019; Accepted June 3, 2019; Published June 15, 2019



Identification of gene clusters in Streptomyces holds promise for the discovery of regulatory pathways linked to bioactive metabolites. We isolated a broad-spectrum antibacterial potential Streptomyces sp BDUSMP 02 from mangrove sediment. We further found a distinct of phylogeny pattern for NRPS A-domain in the Streptomyces sp BDUSMP 02. The result suggests that Streptomyces sp BDUSMP 02 has the potential to produce a new type of antibacterial compounds belonging to NRPS type.



Mangrove, Streptomyces, NRPS, adenylate domain, Phylogeny



Sivalingam et al. Bioinformation 15(6): 412-418 (2019)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.