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Title

Inhibition studies of HBV DNA polymerase using seed extracts of Pongamia pinnata
 

Authors

Manikannan Mathayan1, Selvaraj Jayaraman2, Langeswaran Kulanthaivel3 & Arumugam Suresh*,1

 

Affiliation

1Centre for Drug Discovery and Development, Col. Dr. Jeppiaar Research Park, Sathyabama Institute of Science and Technology, Chennai; 2Department of Biochemistry, Saveetha Dental College & Hospital, Chennai 77; 3Department of Bioinformatics, Science Campus, Alagappa University, Karaikudi

 

Email

Dr. A. Suresh - Email: kpm_suresh@yahoo.com; Phone: +91-9894207006; *Corresponding author

 

Article Type

Research Article

 

Date

Received June 14, 2019; Accepted June 16, 2019; Published July 31, 2019

 

Abstract

Several antiviral compounds for HBV have been identified from traditionally used medicinal plants. We have earlier described the immune modulation properties of P. pinnata, a traditionally used Indian medicinal plant. Therefore, it is of interest to explore the anti-Hepatitis B virus activity of P. pinnata extracts by in-vitro screening assays. This study clearly demonstrated that the 5mg/ml concentration of the aqueous extract significantly inhibited the virus binding. Further, the spectral study was carried out for finding active compounds. The active chalcone derivatives namely, glabaarachalcone, and isopongachromene were isolated from P. pinnata aqueous seed extracts by standard spectral procedures. Virtual screening data shows that glabaarachalcone, and isopongachromene bound with HBV DNA polymerase protein target.

 

Keywords

HBV, DNA polymerase, seed extracts, Pongamia pinnata

 

Citation

Mathayan et al. Bioinformation 15(7): 506-512 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.