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Title

A combined view of B-cell epitope features in antigens
 

Authors

Nayem Zobayer1,*, ABM Aowlad Hossain2 & Md. Asadur Rahman1

 

Affiliation

1Department of Biomedical Engineering, Khulna University of Engineering and Technology, Khulna 9203, Bangladesh; 2Department of Electronics and Communication Engineering, Khulna University of Engineering and Technology, Khulna 9203, Bangladesh

 

Email

Nayem Zobayer E-mail: nayem.rbg@gmail.com; ABM Aowlad Hossain E-mail: aowlad0403@ece.kuet.ac.bd; *Corresponding author

 

Article Type

Research Article

 

Date

Received July 1, 2019; Accepted July 31, 2019; Published August 15, 2019

 

Abstract

B-cell epitope mapping is a promising approach to identify therapeutics and vaccine candidates in antigenic proteins. We used MATLAB programming to view in combination different features such as beta turn region, surface accessibility, antigenicity and hydrophilicity in an antigen sequence to help predict a discontinuous, conformational B-cell epitope. We analyzed, grouped, compared, matched and superposed these features for a combined visualization using MATLAB programming for identifying and illustrating a potential B-cell epitope region in an antigen protein. This protocol finds application in the design and development of an effective B cell epitope candidate.

 

Keywords

B-cell, epitope, features, antigens, MATLAB

 

Citation

Zobayer et al. Bioinformation 15(7): 530-534 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.