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Title

Molecular docking analysis of a secondary metabolite with the glycoprotein receptors of HSV 1 and HSV 2

 

Authors

Natarajan Saran1,2, Balaiyah Anandharaj2, Giridharan Bupesh1,3,*, Sakthivel Vasanth3, Joseph Pinto Jasmine Beulah3, Vellingiri Balachandar4

 

Affiliation

1Department of Virology, King Institute of Preventive Medicine and Research, Chennai, India; 2Department of Microbiology, M.R. Government College, Mannargudi, India; 3Research & Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, BIHER, Chrompet, Chennai - 600044, Tamil Nadu, India; 4Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore Tamil Nadu, India

 

Email

Dr. G. Bupesh - E-mail: bupeshgiri55@gmail.com; Phone +91 8012405965; *Corresponding author

 

Article Type

Research Article

 

Date

Received October 18, 2019; Revised December 18, 2019; Accepted December 25, 2019; Published December 31, 2019

 

Abstract

Herpes simplex viruses (HSV) are alpha herpes viruses, which causes life-threatening illness. Therefore, it is of interest to design and develop potential drugs to treat HSV infections. We show the optimal molecular docking properties of a secondary metabolite (3, 7, 11, 15 tetra methyl-2-2-hexadecen-1-ol) with the glycoprotein receptors of HSV1 and HSV 2 for further consideration.

 

Keywords

Herpes simplex virus 1 & 2, glycoprotein, PHYTOL, ADMET properties, drug likeliness

 

Citation

Saran et al. Bioinformation 15(12): 887-893 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.