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Title

Protein interaction studies of curli fimbriae in Escherichia coli biofilms

 

Authors

Maithreyi Suresh Iyer, PA Abhinand, CR Hemalatha*

 

Affiliation

Department of Bioinformatics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600 116, India

 

Email

CR Hemalatha Email: hemalatha@sriramachandra.edu.in; Phone: +919884463996; *Corresponding author

 

Article Type

Research Article

 

Date

Received December 9, 2019; Revised December 30, 2019; Accepted December 30, 2019; Published December 31, 2019

 

Abstract

Catheter-associated urinary tract infections (CAUTIs) caused by biofilms on indwelling medical devices are the most common type of nosocomial infections, a major health concern due to complications and frequent recurrence. The infections are most often caused by Escherichia coli. Curli are proteinaceous components of a complex extracellular matrix produced by various strains of Enterobacteriaceae. Curli fibers are involved with adhesion to surfaces, cell aggregation and biofilm formation. Therefore, it is of interest to study the protein interactions in curli biogenesis, identifying proteins involved in curli biogenesis, the interactions and development of a combinatorial library of novel lead molecules against biofilm formation by Escherichia coli. Targeting the CsgG protein of Escherichia coli could provide new treatment modalities to fight CAUTIs, better. This study may also help study infections caused by various strains of Enterobacteriaceae, in general.

 

Keywords

CAUTIs, Escherichia Coli, Biofilms, Curli, Protein-Protein Interaction, Protein Modeling, Drug Discovery, Combinatorial Library

 

Citation

Iyer et al. Bioinformation 15(12): 918-921 (2019)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.