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Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment



Jayaraman Selvaraj1*, Rajagopal Ponnulakshmi2, Srinivasan Abilasha3, DevarajanNalini4, Periyasamy Vijayalakshmi5, Veeraraghavan Vishnupriya1, Surapaneni Krishna Mohan6



1Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 2Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; 3Department of Anatomy, Asan Memorial Dental College & Hospital, Asan Nagar, Chengalpattu, Tamil Nadu; 4Central Research Laboratory, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India; 5DBT-BIF Centre, PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy, Tamilnadu; 6Department of Biochemistry, Pnaimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai-600 123, Tamil Nadu, India; Dr. Selvareaj Jayaraman *Corresponding author.



Selvaraj Jayaraman: jselvaendo@gmail.com; Ponnulakshmi Rajagopal: ramgslaks@gmail.com; Abilasha Srinivasan: abipriya.papu@gmail.com; Nalini Devaraj: nalinikrishu@gmail.com; Vijayalakshmi Periyasamy: pvijibi@gmail.com; Vishnupriya Veeraraghavan: drvishnupriyav@gmail.com; Surapaneni Krishna Mohan: krishnamohan.surapaneni@gmail.com


Article Type

Research Article



Received February 2, 2020; Accepted February 20, 2020; Published February 29, 2020



Colorectal cancer (CRC) is the most familiar malignancy worldwide. Hence, searching for novel therapeutic options is of highest priority. Therefore, it is of interest to design inhibitors to the protein target importin-11, which transports β-catenin linked to colon cancer cells. However, the structure of importin-11 is not known. Hence, we use a homology model of importin-11 to dock potential interactions with five phyto compounds using molecular interaction features for further consideration.



Colon cancer, importin-11, molecular models, molecular docking



Selvaraj et al. Bioinformation 16(2): 153-159 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.