Title

Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment

Authors

Jayaraman Selvaraj¹*, Rajagopal Ponnulakshmi², Srinivasan Abilasha³, DevarajanNalini⁴, Periyasamy Vijayalakshmi⁵, Veeraraghavan Vishnupriya¹, Surapaneni Krishna Mohan⁶

Affiliation

¹Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; ²Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; ³Department of Anatomy, Asan Memorial Dental College & Hospital, Asan Nagar, Chengalpattu, Tamil Nadu; ⁴Central Research Laboratory, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India; ⁵DBT-BIF Centre, PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy, Tamilnadu; ⁶Department of Biochemistry, Pnaimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai-600 123, Tamil Nadu, India; Dr. Selvareaj Jayaraman *Corresponding author.

Email

Selvaraj Jayaraman: jselvaendo@gmail.com; Ponnulakshmi Rajagopal: ramgslaks@gmail.com; Abilasha Srinivasan: abipriya.papu@gmail.com; Nalini Devaraj: nalinikrishu@gmail.com; Vijayalakshmi Periyasamy: pvijibi@gmail.com; Vishnupriya Veeraraghavan: drvishnupriyav@gmail.com; Surapaneni Krishna Mohan: krishnamohan.surapaneni@gmail.com

Article Type

Research Article

Date

Received February 2, 2020; Accepted February 20, 2020; Published February 29, 2020

Colorectal cancer (CRC) is the most familiar malignancy worldwide. Hence, searching for novel therapeutic options is of highest priority. Therefore, it is of interest to design inhibitors to the protein target importin-11, which transports β-catenin linked to colon cancer cells. However, the structure of importin-11 is not known. Hence, we use a homology model of importin-11 to dock potential interactions with five phyto compounds using molecular interaction features for further consideration.

Keywords

Colon cancer, importin-11, molecular models, molecular docking

Citation

Selvaraj et al. Bioinformation 16(2): 153-159 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.