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Increased Gonadotropins and prolactins are linked to infertility in males


Pravin Kumar Gangwar 1 , Satya Narayan Sankhwar1 , Shriya Pant 1, Akhilesh Krishna2, Bhupendra Pal Singh1 Abbas Ali Mahdi3 Rajender Singh4



1Department of Urology, King George’s Medical University, Lucknow, U.P., India; 2Department of Physiology, King George’s Medical University, Lucknow, U.P., India; 3Department of Biochemistry, King George’s Medical University, Lucknow, U.P., India; 4Division of Endocrinology, Central Drug Research Institute, Lucknow, U. P., India;



 Prof. S. N. Sankhwar - sankhwarsn_sn@yahoo.com, Mobile No. +91-9415007703; Dr. Rajender Singh - Email- nainrs@gmail.com, Contact no. 9044872221; *Corresponding authors

Pravin Kumar Gangwar - gangwar.pravin1986@gmail.com; S. N. Sankhwar - sankhwarsn_sn@yahoo.com; Shriya Pant shreyapant.18sep@gmail.com; Dr. Akhilesh Krishna2 - akhil.kgmc@gmail.com; Rajender Singh- bpsingh@kgmcindia.edu;
abbasalimahdi@kgmcindia.edu; nainrs@gmail.com


Article Type

Research Article



Received January 24, 2020; Accepted February 20, 2020; Published February 29, 2020



Infertility has become a significant issue among married couples worldwide. The association of variations in reproductive hormones with infertility is evaluated at a tertiary care hospital in North India. A total of 220 infertile males having infertility longer than one year (cases) and 220 age-matched fertile males with confirmed paternity in past two to three years (controls) were enrolled for the study. Serum levels of LH, FSH, testosterone and PRL were measured by Roche e411 autoanalyzer using electrochemiluminescense immunoassay technique. Significant higher levels of serum hormone (mean±SD) were found in cases vs. controls; LH (9.02±7.81 vs. 5.22±1.45 mIU/ml), FSH (11.45±14.02 vs. 4.09±1.62 mIU/ml) and PRL (199.08±80.79 vs. 127.23±81.64 μIU/ml). However, the serum testosterone level was significantly low in cases associated with male infertility (4.62±2.03 vs. 6.82±2.79 ng/ml). LH, FSH and PRL levels were significantly increased in azoospermic, oligozoospermic and asthenozoospermic infertile males while FSH and PRL were significantly elevated in normozoospermic infertile group. Conversely, mean serum testosterone levels were significantly low in all infertile subgroups in comparison to fertile controls. PRL showed a significant prediction of Normozoospermia (AUC=0.836, Z=4.916, p<0.001) in ROC analysis. Data presented here is interesting, requiring further confirmation using larger samples of multiple cohorts.



Hormones, male infertility, spermatogenesis.



Gangwar et al. Bioinformation 16(2): 176-182 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.