Title

Molecular modeling and docking analysis of aspirin with pde7b

Authors

Arthi Balasundaram¹*, Darling Chellathai David¹

Affiliation

¹Department of Pharmacology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai-116, Tamil Nadu, India.

Email

*Address for Correspondence: Dr Arthi Balasundaram MD. PhD - Email IDrtms86@yahoo.com.

Article Type

Research Article

Date

Received January 20, 2020; Accepted February 20, 2020; Published February 29, 2020

The PDE7B gene encodes 3'5'-cyclic nucleotide phosphodiesterase (PDE) and a known target in cognitive impairments. Therefore, it is of interest to design and development of potential inhibitors with PDE7B with improved binding features. We document that the amino acid
residues such as H186, K190, and G113 of PDE7B protein showed crucial interactions with aspirin for further consideration in this context.

Keywords

aspirin, PDE7B, cognitive impairments, molecular docking, homology modelling

Citation

Balasundaram & David, 16(2): 183-188 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.