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Analysis of methyltransferase (MTase) domain from Zika virus (ZIKV)



Sarah Afaq1*, Arshi Malik2, Akhtar Atiya3, Afaf S. Alwabli4, Dhafer A. Alzahrani5, Habeeb M. Al-
Solami6, Othman Alzahrani7, Qamre Alam8, Mohammad Azhar Kamal9,10 & Aala A. Abulfaraj11



1,2Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia; 3Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia; 4,5,6Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; 7Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia; 8Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of
Saudi Arabia; 9Department of Biochemistry, Faculty of Science, University of Jeddah, Jeddah, Kingdom of Saudi Arabia; 10University of Jeddah Center for Science and Medical Research (UJC-SMR), Jeddah, Kingdom of Saudi Arabia; 11Department of Biology, Science and Arts College, Rabigh Campus, King Abdulaziz University, Jeddah, Saudi Arabia;



Dr. Sarah Afaq - Email: safaq@kku.edu.sa; *Corresponding author Arshi Malik - E-mail: amalik@kku.edu.sa; Akhtar Atiya - E-mail: akhan@kku.edu.sa; Afaf S. Alwabli - E-mail: aalwabili@stu.kau.edu.sa; Dhafer A. Alzahrani - E-mail: dalzahrani@kau.edu.sa; Habeeb M. Al-Solami - E-mail: hmalsolami@kau.edu.sa; Othman Alzahrani - E-mail:
o-alzahrani@ut.edu.sa; Qamre Alam - E-mail: alamqa@ngha.med.sa; Mohammad Azhar Kama - E-mail: maksmal@uj.edu.sa; Aala A. Abulfaraj - E-mail: aaabulfaraj@kau.edu.sa
Submitted by Dr. Mohammad Tarique, Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi-110025, India; E-mail id: tariqueaiims@gmail.com


Article Type

Research Article



Received October 22, 2019; Revised February 15, 2020, Accepted February 20, 2020; Published March 31, 2020



A comprehensive analysis of methyltransferase (MTase) from Zika virus (ZIKV) is of interest in the development of drugs and biomarkers in the combat and care of ZIKA fever with impulsive joint pain and conjunctivitis. MTase sequence is homologous in several viral species. We analyzed the MTase domain from ZIKV using Bioinformatics tools such as SMART, PROSITE, PFAM, PANTHER, and InterProScan to glean insights on the sequence to structure to function data. We document inclusive information on MTase from ZIKV for application in the design of drugs and biomarkers to fight against the disease.



ZIKV, methyltransferase, beta turn, α-helix, SMART, Prosite, Pfam and InterProScan



Afaq et al. 16(3): 229-235 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.