HOME   |    PDF   |   


Distinctive features gleaned from the comparative genomes analysis of clinical and non-clinical isolates of Klebsiella pneumoniae



Jina Rajkumari1, Supriyo Chakraborty2*, Piyush Pandey1*



1Department of Microbiology, Assam University, Silchar 788011, Assam, India; 2Department of Biotechnology, Assam University, Silchar 788011, Assam, India



Piyush Pandey and Supriyo Chakraborty - Email: piyushddn@gmail.com,  supriyoch_2008@rediffmail.com


Article Type

Research Article



Received January 29, 2020; Revised March 10, 2020, Accepted March 15, 2020; Published March 31, 2020



It is of interest to describe the distinctive features gleaned from the comparative genome analysis of clinical and non-clinical isolates of Klebsiella pneumoniae. The core genome of K. pneumoinae consisted of 3568 genes. Comparative genome analysis shows that mdtABCD, toxinantitoxin systems are unique to clinical isolates and catB, benA, and transporter genes for citrate utilization are exclusive to non-clinical isolates. We further noted aromatic compound degrading genes in non-clinical isolates unlike in the later isolates. We grouped 88 core genes into 3 groups linked to infections, drug-resistance or xenobiotic metabolism using codon usage variation analysis. It is inferred using the neutrality plot analysis of GC12 with GC3 that codon usage variation is dominant over mutation pressure. Thus, we document data to distinguish clinical and non-clinical isolates of K. pneumoniae using comparative genomes analysis for understanding of genome diversity during speciation.



Klebsiella pneumoniae, Comparative genomics, Codon usage bias



Rajkumari et al. Bioinformation 16(3): 256-266 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.