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A comparative study of antibacterial and antifungal activities of extracts from four indigenous plants



Rajendra Mehta1; Suraj Dhruv1; Vidyanshu Kaushik1; Kamal Kumar Sen1; Naureen Shaba Khan2; Amar Abhishek3; Ashwini Kumar Dixit3 and Vibhay Nath Tripathi3#



1Department of Rural Technology, Guru Ghasidas University, Bilaspur, India 495009; 2Department of Botany, Dr. C. V. Raman University, Bilaspur, India 495113; 3Department of Botany, Guru Ghasidas University, Bilaspur, India 495009;



Vibhay Nath Tripathi - Phone: +91-7587879195; E-mail: vibhay.tripathi@ggu.ac.in; *Corresponding author.


Article Type

Research Article



Received February 19, 2019; Revised March 5, 2020, Accepted March 17, 2020; Published March 31, 2020



A repetitive and wide use of chemical antibiotics has brought a serious threat in the biomedical and clinical sectors by the emergence of multidrug resistant pathogens. Plants have secondary metabolites that make them suitable candidate for natural antimicrobial agent without any side effect. In this study, we assessed comparative antibacterial and antifungal effects of extracts from four Indigenous plants (Nerium sp; Mentha sp; Aloe vera and Eucalyptus sp). Total phenolic and flavonoid content were extracted by microwave-assisted extractor and used for phytochemical assay. Antimicrobial experiment was done by micro dilution technique. A post hoc analysis inbuilt with oneway ANOVA test was used for the compilation of antibiotic sensitivity data and percent inhibition. Total phenolic content and Flavonoids were significantly highest in E2 and lowest in E1 (All p<0.05). In antibacterial and antifungal activity higher concentrations of extracts showed a strong activity, which was as good as antibiotics used as control. Results from Eucalyptus sample showed a significant growth reducing capability even at lower concentrations. This study concludes that the plant extracts can be used to treat microbial infections with almost same efficacy as antibiotics and with a lower chance of resistance development.



Antibiotic sensitivity; Mentha spp; Aloe vera; Nerium oleander and Eucalyptus spp



Mehta et al. Bioinformation 16(3): 267-273 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.