Title

Molecular docking analysis of piperine with CDK2, CDK4, Cyclin D and Cyclin T proteins

Authors

Umaphathy Vidhya Rekha^1,*, M. Anita¹, Govindaraj Jayamathi², K. Sadhana¹, Subramanian Deepa³, Sajid Hussain³, J. Bhuvaneswari³, V. Ramya³, Jayaraman Selvaraj⁴

Affiliation

¹Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; ²Department of Biochemistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; ³Department of Periodontics, Sree Balaji Dental
College and Hospital, Pallikaranai, Chennai-600 100, India; ⁴Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India

Email

Dr. Umaphathy Vidhya Rekha - Email: drvidhyarekha@gmail.com; *Corresponding author

Article Type

Research Article

Date

Received March 3, 2019; Revised April 1, 2020, Accepted April 10, 2020; Published May 31, 2020

Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates. Therefore, it is of interest to understand the molecular docking interactions of piperine with several cell cycle proteins such as Cyclin dependent kinase 2 (CDK2), Cyclin-dependent kinase 4 (CDK4), Cyclin D and Cyclin T for further consideration in drug discovery related to oral cancer.

Keywords

Piperine, CDK2, CDK4, Cyclin D and Cyclin T, cell cycle regulators, oral cancer, molecular docking

Citation

Vidhya Rekha et al. Bioinformation 16(5): 359-362 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.