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Title

Molecular docking analysis of N-substituted oseltamivir derivatives with the SARS-Cov-2 main protease

 

Authors

Assia Belhassan1, Samir Chtita2, Hanane Zaki1, Tahar Lakhlifi1 and Mohammed Bouachrine1,3*

 

Affiliation

1Molecular Chemistry and Natural Substances Laboratory, Faculty of Science, Moulay Ismail University of Meknes, Morocco; 2Laboratory of physical chemistry and materials, Faculty of science Ben MíSik, Hassan II University of Casablanca, Casablanca, Morocco; 3EST Khenifra, Sultan Moulay Sliman University,

 

Email

Benimellal, Morocco; *Corresponding Author: E-mail: m.bouachrine@est-umi.ac.ma &
bouachrine@gmail.com

 

Article Type

Research Article

 

Date

Received April 6, 2020; Revised April 22, 2020; Accepted April 22, 2020; Published May 31, 2020

 

Abstract

The identification of chemotherapeutic drugs against Novel Coronavirus (2019-nCoV) is a significant requirement due to the rapid rise in deaths due to Corona Viral Infection all around the world. Therefore, it is of interest to document the molecular docking analysis data of 32 N-substituted Oseltamivir derivatives inhibitors of influenza virus H5N1 with the Novel Coronavirus main protease (2019-nCoV). We describe the optimal binding features of Oseltamivir derivatives with the SARS-Cov-2 main protease (Code PDB: 6LU7) for further consideration.

 

Keywords

Coronavirus, COVID-19, SARS-CoV-2, oseltamivir, H5N1, molecular docking

 

Citation

Belhassan et al. Bioinformation 16(5): 404-410 (2020)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.