Title
A report on DNA sequence determinants in gene expression
Authors
Ravail Singh1,#, & Yengkhom Sophiarani2,#
Affiliation
1Indian Institute of Integrative Medicine, CSIR, Canal Road, Jammu-180001; 2Department of Biotechnology, Assam University, Silchar-788011, Assam, India
Ravail Singh - Email: ravailsin91@gmail.com; rubail2010@googlemail.com; Yengkhom Sophiarani- Email: Sophia.yengkhom90@gmail.com; #Equal contribution; *Corresponding author: Ravail Singh
Article Type
Research Article
Date
Received April 23, 2020; Accepted April 24, 2020; Published May 31, 2020
Abstract
The biased usage of nucleotides in coding sequence and its correlation with gene expression has been observed in several studies. A complex set of interactions between genes and other components of the expression system determine the amount of proteins produced from coding sequences. It is known that the elongation rate of polypeptide chain is affected by both codon usage bias and specific amino acid compositional constraints. Therefore, it is of interest to review local DNA-sequence elements and other positional as well as combinatorial constraints that play significant role in gene expression.
Keywords
Gene expression; codon; amino acid; genome
Citation
Singh & Sophiarani, Bioinformation 16(5): 422-431 (2020)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
