From sequence analysis of DPP-4 to molecular docking based searching of its inhibitors

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Title	From sequence analysis of DPP-4 to molecular docking based searching of its inhibitors
Authors	Awad Saeed Alsamghan¹, Afaf S. Alwabli^2,, Mohammed Abadi³, Safar A. Alsaleem⁴, Dalia Mohammed Anbari⁵, Amani Saleh Alomari⁶, Othman Alzahrani^7,8, Qamre Alam⁹ & Mohammed Tarique^10,
Affiliation	¹Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha, KSA-61421; ²Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; ^3,4Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha, KSA-61421. ^5,6Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; ⁷Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk 71491, Kingdom of Saudi Arabia; 8Genome and Biotechnology Unit, University of Tabuk, Tabuk 71491, Kingdom of Saudi Arabia; 9Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia; 10Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi-110025, India.
Email	Dr. Afaf S. Alwabli- Email: afafalwabli@yahoo.com; Dr. Mohammed Tarique - E-mail id: tariqueaiims@gmail.com; *Corresponding author with equal contribution
Article Type	Research Article
Date	Received March 3, 2020; Revised April 19, 2020; Accepted May 7, 2020; Published June 30, 2020
Abstract	Literature data suggests that Dipeptidyl peptidase-4 (DPP-4) is a potential target for type 2 Diabetes Mellitus. Therefore, it is of interest to identify new DPP-4 inhibitors using molecular docking analysis. We document compounds such as STOCK1N-98884, STOCK1N-98881, and STOCK1N-98866 with optimal binding features with DPP-4 from the ligand database at https://www.ibscreen.com/ for further consideration.
Keywords	DPP-4, GLP-1, diabetes, docking analysis, inhibitor
Citation	Alsamghan et al. Bioinformation 16(6): 444-451 (2020)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.