Title

Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9

Authors

Chandrasekaran Kirubhanand¹ Jayaraman Selvaraj², Umapathy Vidhya Rekha³, Veeraraghavan Vishnupriya², DevarajanNalini⁴, Surapaneni Krishna Mohan⁵, Periyasamy Vijayalakshmi⁶, Manikkam Rajalakshmi⁶, Rajagopal Ponnulakshmi⁷,*

Affiliation

¹Department of Anatomy, All India Institute of Medical Sciences, Nagpur, India; ²Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; ³Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; ⁴Central Research Laboratory, Meenakshmi Ammal Dental College, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 095, India; ⁵Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai-600 123, Tamil Nadu, India; ⁶DBTBIF Centre, PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy, Tamilnadu, India; ⁷Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), West K. K. Nagar, Chennai-600 078, India.

Email

Dr. Rajagopal Ponnulakshmi E-mail: ramgslaks@gmail.com; *Corresponding author

Article Type

Research Article

Date

Received March 3, 2020; Revised April 19, 2020; Accepted May 8, 2020; Published June 30, 2020

Several apoptotic signalling proteins such as Bax, Caspase 3, Cox 2 and Caspase 9 are known to be associated with colorectal cancer (CRC). It is of interest to study the interaction of these proteins with piperine a known drug candidate. We document the binding energy, hydrogen bond interaction and hydrophobic interaction between the piperine and apoptotic proteins for further consideration.

Keywords

Piperine, molecular docking, Bax, Caspase 3, Cox 2 and Caspase 9

Citation

Kirubhaanad et al. Bioinformation 16(6): 458-461 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.