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Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9



Chandrasekaran Kirubhanand1 Jayaraman Selvaraj2, Umapathy Vidhya Rekha3, Veeraraghavan Vishnupriya2, DevarajanNalini4, Surapaneni Krishna Mohan5, Periyasamy Vijayalakshmi6, Manikkam Rajalakshmi6, Rajagopal Ponnulakshmi7,*



1Department of Anatomy, All India Institute of Medical Sciences, Nagpur, India; 2Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 3Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; 4Central Research Laboratory, Meenakshmi Ammal Dental College, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 095, India; 5Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai-600 123, Tamil Nadu, India; 6DBTBIF Centre, PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy, Tamilnadu, India; 7Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), West K. K. Nagar, Chennai-600 078, India.



Dr. Rajagopal Ponnulakshmi E-mail: ramgslaks@gmail.com; *Corresponding author


Article Type

Research Article



Received March 3, 2020; Revised April 19, 2020; Accepted May 8, 2020; Published June 30, 2020



Several apoptotic signalling proteins such as Bax, Caspase 3, Cox 2 and Caspase 9 are known to be associated with colorectal cancer (CRC). It is of interest to study the interaction of these proteins with piperine a known drug candidate. We document the binding energy, hydrogen bond interaction and hydrophobic interaction between the piperine and apoptotic proteins for further consideration.



Piperine, molecular docking, Bax, Caspase 3, Cox 2 and Caspase 9



Kirubhaanad et al. Bioinformation 16(6): 458-461 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.