HOME   |    PDF   |   


Title

Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives

Authors

Krishnamoorthy Meenakumari & Giridharan Bupesh*

 

Affiliation

Research and Development Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital (SBMCH), BIHER, Chrompet, Chennai - 600044, India

 

Email

Dr. Giridharan Bupesh, - Phone: +91 8012405965, Email: bupeshgiri55@gmail.com.

 

Article Type

Research Article

 

Date

Received January 3, 2020; Revised April 30, 2020; Accepted May 8, 2020; Published June 30, 2020

 

Abstract

It is of interest to document the molecular docking of C-Jun-N-Terminal Kinase (Jnk) (known structure with PDB ID: 1PMN) with aminopyrimidine derivatives in the context of Alzheimer’s Disease (AD). We report the optimal binding features (binding energy, interacting residues, inter atomic hydrogen bonding patterns) of 11 amino-pyrimidine derivatives with Jnk for further consideration.

 

Keywords

JNK3, inhibitors, amino-pyrimidine

 

Citation

Meenakumari & Bupesh, Bioinformation 16(6): 462-467 (2020)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.