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Comparative thermo-stability of two Rift Valley fever virus vaccine candidate 13T with a recombinant arMP-12 delta NSm21/384 protein



S Daouam1,2,**, Z Boumart1,**, A Elarkam1, J Hamdi1, KO Tadlaoui1, MM Ennaji2,* & MEL harraka



1Research and Development Virology, Multi-Chemical Industry, Morocco; 2Laboratory of Virology, Microbiology, Quality and Biotechnology/ETB, Faculty of Sciences & Technics Mohammedia, Morocco



Tel: +212 661-748862; E-mail: m.ennaji@yahoo.fr; *Corresponding author; **Equal Contribution


Article Type

Research Article



Submitted on March 16, 2020; Revision June 1, 2020; Accepted June 10, 2020; Published July 31, 2020



Rift Valley fever (RVF) is a zoonotic, viral disease, transmitted by mosquitoes, characterized by high mortality rates in young animals. RVF is an endemic and enzootic disease in the Arabian Peninsula and Africa, causing public health and economic instability. Therefore, it is important to develop vaccines to minimize outbreaks and combat the disease. We documented the stability of the thermo-stability of live attenuated RVF CL13T and recombinant arMP-12 delta NSm21/384 vaccine candidates at different temperatures, including these vaccine viruses in liquid and lyophilized form. The study revealed that both CL13T and recombinant arMP-12 delta NSm21/384 strains were stable for more than 18 months at 4C. We show that at room temperatures (37C and 45C) the CL13T was less temperature sensitive than MP-12NSm-del in both lyophilized and liquid form. These findings are useful for the preparation of RVF vaccines that will avoid the need for a cold chain and therefore, will improve the application of the vaccines under field conditions.



Stability, Clone 13T vaccine, arMP-12 delta NSm21/384 vaccine.



Daouam et al. Bioinformation 16(7): 547-554 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.