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Title

Molecular docking analysis of DNA ligase from Staphylococcus aureus with identical polysaccharides

 

Authors

Anitha Roy1, Aneymole Varikalam Sleeba2, Rini Joy3, Ponnulakshmi Rajagopal4

 

Affiliation

1Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India; 2Department of Microbiology, St. Xavier’s College for Women, Aluva, Kerala-683101, India; 3Department of Oral Medicine and Radiography, SRM Dental College and Hospitals, Ramapuram, Chennai - 600089, Tamil Nadu, India; 4Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be Universiy) Chennai-600 078, India

 

Email

*Corresponding author: Dr. Anitha Roy - Email: anitharoy2015@gmail.com

 

Article Type

Research Article

 

Date

Submitted on July 31, 2020; Revision August 13, 2020; Accepted August 13, 2020; Published September 30, 2020

 

Abstract

Staphylococcus aureus has been recognized as an important human pathogen for more than 100 years. DNA ligase is the main protein responsible for the replication of S. aureus. DNA ligase was selected as successive target to control the replication mechanism. The antibacterial activity of polysaccharide is known. Therefore, it is of interest to study the activity of Polysaccharide analogues against DNA ligase in S. aureus using molecular docking analysis. We report ten analogues using scoring parameters with best two analogues as potential drug candidate for the combat of S. aureus infection.

 

Keywords

S. aureus, DNA ligase, Polysaccharide, Molecular docking

 

Citation

Roy et al. Bioinformation 16(9): 719-724 (2020)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.