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Molecular docking analysis of aspirin analogues with β-catenin


Jayaraman Selvaraj1, Hussain Sardar2, Veeraraghavan Vishnupriya3, Janardhana Papayya Balakrishna4, Surapaneni Krishna Mohan5, Rajamanickam Pon Nivedha6, Periyasamy Vijayalakshmi7, Rajagopal Ponnulakshmi8*



1,3Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 2Department of Biotechnology, Government Science College, Chitradurga-577501, Karnataka, India; 4Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor, 10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, India; 5Department of Biochemistry and Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; 6Exonn Biosciences, Ticel Bio Park, Chennai-600 0113, India; 7PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy620002, Tamil Nadu, India; 8Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India



Dr. Rajagopal Ponnulakshmi - ramgslaks@gmail.com; *Corresponding author


Article Type

Research Article



Submitted on May 14, 2020; Revision August 14, 2020; Accepted August 14, 2020; Published September 30, 2020



Canonical Wnt signaling pathway plays a crucial role in cancer cell proliferation, which links by the growth of β-catenin in cell due to inactivation of glycogen synthetase kinase-3. Therefore, it is of interest to design novel candidates to bind with β-catenin. Hence, we document the molecular docking analysis data of aspirin analogues with β-catenin for further consideration.



Colon cancer, Wnt signaling, molecular docking, ADME



Selvaraj et al. Bioinformation 16(9): 725-730 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.