Title

Molecular docking analysis of aspirin analogues with β-catenin

Authors

Jayaraman Selvaraj¹, Hussain Sardar², Veeraraghavan Vishnupriya³, Janardhana Papayya Balakrishna⁴, Surapaneni Krishna Mohan⁵, Rajamanickam Pon Nivedha⁶, Periyasamy Vijayalakshmi⁷, Rajagopal Ponnulakshmi^8*

Affiliation

^1,3Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; ²Department of Biotechnology, Government Science College, Chitradurga-577501, Karnataka, India; ⁴Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor, 10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, India; ⁵Department of Biochemistry and Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ⁶Exonn Biosciences, Ticel Bio Park, Chennai-600 0113, India; ⁷PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy620002, Tamil Nadu, India; ⁸Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India

Email

Dr. Rajagopal Ponnulakshmi - ramgslaks@gmail.com; *Corresponding author

Article Type

Research Article

Date

Submitted on May 14, 2020; Revision August 14, 2020; Accepted August 14, 2020; Published September 30, 2020

Canonical Wnt signaling pathway plays a crucial role in cancer cell proliferation, which links by the growth of β-catenin in cell due to inactivation of glycogen synthetase kinase-3. Therefore, it is of interest to design novel candidates to bind with β-catenin. Hence, we document the molecular docking analysis data of aspirin analogues with β-catenin for further consideration.

Keywords

Colon cancer, Wnt signaling, molecular docking, ADME

Citation

Selvaraj et al. Bioinformation 16(9): 725-730 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.