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Protein targets in the red complex organisms binding with an herbal compound silymarin



Nadhirah Faiz, Keshaav Krishnaa Pothapur, V. Vishnu Priya*, R. Gayathri, J. Vijayashree



Saveetha Dental College and Hospitals, Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha University Chennai 600077, Tamilnadu, India;



R. Gayathri - Email ID: gayathri.sdc@saveetha.com; V. Vishnu Priya - Email ID:
vishnupriya@saveetha.com; *Corresponding author


Article Type

Research Article



Submitted on July 9, 2020; Revision September 8, 2020; Accepted September 9, 2020; Published October 31, 2020



Periodontitis is attributed to the dental biofilm formation caused by various microbial changes that occurs in the biofilm. Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound silymarin. We report a list of potential proteins having optimal drug like binding features with the herbal agent silymarin for further consideration. We used the STITCH v.5 pipeline using VICMPred and VirulentPred tools to identify such targets as potential virulent factors in the red complex organisms. We considered the strains of Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 in the red complex pathogens for this analysis. Protein targets in the red complex organisms with optimal binding features with the herbal compound silymarin were thus identified and reported for further consideration.



Protein targets, red complex organisms, silymarin



Faiz et al. Bioinformation 16(10): 759-764 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.