Title
Identification of protein targets in red complex organisms binding with resveratrol
Authors
Keshaav Krishnaa Pothapur, Veeraraghavan Vishnu Priya, Gayathri Rengasamy & Vijayashree Priyadharsini Jayaseelan
Affiliation
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University Chennai, Tamil Nadu, India
Veeraraghavan Vishnu Priya - drvishnupriyav@gmail.com; *Corresponding author
Article Type
Research Article
Date
Received September 8, 2020; Revision September 27, 2020; Accepted September 27, 2020; Published November 30, 2020
Abstract
Periodontitis is attributed to the dental biofilm formation caused by various Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound resveratrol (E - 5 - (4 - hydroxy styryl) benzene 1,3 diol). We report a list of potential proteins having optimal drug like binding features with the herbal agent Resveratrol for further consideration. We used the STITCH v.5 pipeline using VICMPred and VirulentPred tools to identify such targets as potential virulent factors in the red complex organisms. We considered the strains of Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 in the red complex pathogens for this analysis. Protein targets in the red complex organisms with optimal binding features with the herbal compound resveratrol were thus identified and reported for further consideration.
Keywords
Protein targets, red complex organisms, resveratrol
Citation
Pothapur et al. Bioinformation 16(11): 837-842 (2020)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
