Title

Molecular docking analysis of C-phycocyanin with VEGFR2

Authors

Saira M Bannu¹, Dakshayani Lomada^2*, Sravani Varala¹ & Madhava C. Reddy^1*

Affiliation

¹Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa AP 516005, India; ²Department of Genetics and Genomics, Yogi Vemana University, Kadapa, AP 516005, India

Email

Madhava C Reddy - cmadhavareddy@gmail.com (MCR) or dlomada@yahoo.com (DL); * Corresponding author

Article Type

Research Article

Date

Received September 30, 2020; Revised October 21, 2020; Accepted October 21, 2020; Published November 30, 2020

C-phycocyanin (C-PC) produced from cyanobacterial species finds application in drug development. Therefore, it is of interest to document the molecular binding features of C-PC with the vascular endothelial growth factor receptor 2 (VEGFR2). C-PC showed H-bond interactions with residues on both sides of the Deusche Forschugsgemein-Schalt (DFG) loop (Asp1046-Phe1047-Gly1048). A hydrophobic association between the activation loop and the DFG residue (Gly1048) helps to inhibit the activity of VEGFR2 kinases. Thus, C-PC is reported as a potential angiogenesis inhibitor for VEGFR2 in combating cancer.

Keywords

Molecular docking; C-Phycocyanin; VEGFR2; Angiogenesis; Cancer treatment

Citation

Bannu et al. Bioinformation 16(11): 869-877 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.