Title

Molecular docking analysis of phytocompounds from Andrographis paniculata binding with proteins in the notch-signaling pathway

Authors

Sumetha Suga Deiva Suga¹, Surapaneni Krishna Mohan², Radhika Nalinakumari Sreekandan³, Malathi K⁴, Devakumar Kamaraj⁵, Vishnupripa Veeraraghavan⁶, Selvaraj Jayaraman^7*, Ponnulakshmi Rajagopal⁸

Affiliation

¹Department of Microbiology, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ²Department of Biochemistry and Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ³Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ⁴Department of Biochemistry and Department of Research, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ⁵Department of Pharmacology, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; ^6,7Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Velappanchavadi, Chennai-600 077, India; ⁸Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), West K.K. Nagar, Chennai-600 078, India

Email

Dr. Selvaraj Jayaraan, Email: jselvaendo@gmail.com; *Corresponding Author*

Article Type

Research Article

Date

Received October 2, 2020; Revised October 23, 2020; Accepted October 23, 2020; Published November 30, 2021

It is of interest to document the molecular docking analysis of phytocompounds from Andrographis paniculata binding with protein NOTCH1 in the Notch-signaling pathway in the context of cancer. Hence, we document the binding features of neoandrographolide, 14- deoxyandrographolide, androgapholide and andrograpanin with proteins in the notch-signaling pathway for further consideration.

Keywords

Gastric Cancer; Notch signaling pathway; Andrographis paniculata; Molecular docking studies.

Citation

Deiva Suga et al. Bioinformation 16(11): 923-928 (2020)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.