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Title

In vitro and molecular docking studies of an antiinflammatory scaffold with human peroxiredoxin 5 and tyrosine kinase receptor

 

Authors

R. Bharathi & N. Santhi*

 

Affiliation

Research and development centre, Bharathiar university, Coimbatore, 641046, India; Department Of Chemistry, Govt Arts College, C. Mutlur, Chidambaram 608102, India

 

Email

*Corresponding author; N Santhi – E-mail: nsanthigac@gmail.com

 

Article Type

Research Article

 

Date

Received October 2, 2020; Revised October 24, 2020; Accepted October 24, 2020; Published November 30, 2021

 

Abstract

A new series of 4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile (4a-h) compounds were synthesized and evaluated for in-vitro anti-inflammatory activities. The spectral (IR, NMR) and elemental analyses data of the product indicated the formation of new pyrazoles 4a-h. Compound 4e exhibited potent anti-inflammatory property with 85.45 % inhibitions. This value was compared with standard diclofenac sodium. This data is explained using molecular docking analysis of receptor-ligand binding. These results demonstrated that pyrazole derivatives are potential inhibitors of Human Peroxiredoxin 5 and Tyrosine kinase receptor in the treatment of inflammation related illness.

 

Keywords

in vitro anti-inflammatory, pyrazoline, docking, autodock

 

Citation

Bharathi & Santhi, Bioinformation 16(11): 929-936 (2020)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.