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Title

Cytotoxic, antioxidant, and antimicrobial activities of Celery (Apium graveolens L.)

Authors

Mohammed Saleh Al Aboody

 

Affiliation

Department of Biology, College of Science, Al-Zulfi-, Majmaah University, Majmaah- 11952, Riyadh region Kingdom of Saudi Arabia;

 

Email

Email: m.alaboudi@mu.edu.sa;

 

Article Type

Research Article

 

Date

Received November 24, 2020; Revised December 31, 2020; Accepted January 26, 2020, Published January 31, 2021

 

Abstract

Celery (Apium graveolens Linn, Family: Apiaceae) is a common edible herb used as a spice in the traditional medicine of several nations since time immemorial. The whole plant is extensively used in cooking as soups and salads. A. graveolens has various pharmacological properties such as anticancer, anti-obesity, anti-hepatotoxic, and antihypertensive agents. Hence, it is of interest to document the in vitro cytotoxic, antioxidant, and antimicrobial activity of A. graveolens. The plants were collected in the local market, shade dried, and different parts of the plants were extracted with 70% ethanol using a cold maceration process. Antioxidant tests were performed based on the
various radical scavenging methods. Antimicrobial activity and MIC were completed using the respective cup-plate and two-fold serial dilution method. In vitro cytotoxic studies were achieved by the MTT; Sulphorhodamine B assayed total cell protein content. DLA and ESC cells determined the short-term toxicity. The leaf extract exhibited significant antioxidant properties against NO, DPPH, ABTS, LPO, and HPO methods. Thus, potential inhibition against Gram-positive, Gram-negative, and fungal strains within the MIC ranges of 250-500 μg/ml was observed. All the extracts of the plant presented in the study revealed greater cytotoxicity effects against five respective cancer cell lines, L6, Vero, BRL 3A, A-549, L929, and L-929 with the ranging of 443-168.5 μg/ml. Thus, we show that A. graveolens possess a potential cytotoxic, antioxidant, and antimicrobial activity.

 

Keywords

Apium graveolens Linn, cytotoxic, antioxidant, and antimicrobial activity.

 

Citation

Al Aboody, Bioinformation 17(1): 147-156 (2021)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.