Cytotoxic, antioxidant, and antimicrobial activities of Celery (Apium graveolens L.)

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Title	Cytotoxic, antioxidant, and antimicrobial activities of Celery (Apium graveolens L.)
Authors	Mohammed Saleh Al Aboody
Affiliation	Department of Biology, College of Science, Al-Zulfi-, Majmaah University, Majmaah- 11952, Riyadh region Kingdom of Saudi Arabia;
Email	Email: m.alaboudi@mu.edu.sa;
Article Type	Research Article
Date	Received November 24, 2020; Revised December 31, 2020; Accepted January 26, 2020, Published January 31, 2021
Abstract	Celery (Apium graveolens Linn, Family: Apiaceae) is a common edible herb used as a spice in the traditional medicine of several nations since time immemorial. The whole plant is extensively used in cooking as soups and salads. A. graveolens has various pharmacological properties such as anticancer, anti-obesity, anti-hepatotoxic, and antihypertensive agents. Hence, it is of interest to document the in vitro cytotoxic, antioxidant, and antimicrobial activity of A. graveolens. The plants were collected in the local market, shade dried, and different parts of the plants were extracted with 70% ethanol using a cold maceration process. Antioxidant tests were performed based on the various radical scavenging methods. Antimicrobial activity and MIC were completed using the respective cup-plate and two-fold serial dilution method. In vitro cytotoxic studies were achieved by the MTT; Sulphorhodamine B assayed total cell protein content. DLA and ESC cells determined the short-term toxicity. The leaf extract exhibited significant antioxidant properties against NO, DPPH, ABTS, LPO, and HPO methods. Thus, potential inhibition against Gram-positive, Gram-negative, and fungal strains within the MIC ranges of 250-500 μg/ml was observed. All the extracts of the plant presented in the study revealed greater cytotoxicity effects against five respective cancer cell lines, L6, Vero, BRL 3A, A-549, L929, and L-929 with the ranging of 443-168.5 μg/ml. Thus, we show that A. graveolens possess a potential cytotoxic, antioxidant, and antimicrobial activity.
Keywords	Apium graveolens Linn, cytotoxic, antioxidant, and antimicrobial activity.
Citation	Al Aboody, Bioinformation 17(1): 147-156 (2021)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.