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Title

Molecular docking analysis of SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) with compounds from Plectranthus amboinicus

 

Authors

Jayaraman Selvaraj1,*, Umapathy Vidhya Rekha2, Shazia Fathima JH3, Venkatacalam Sivabalan4,
Rajagopal Ponnulakshmi5, Veeraraghavan Vishnupriya1, Malathi Kullappan6, Radhika nalinakumari Sreekandan7 Surapaneni Krishna Mohan8

 

Affiliation

1Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 2Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; 3Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India; 4Department of Biochemistry, KSR Institute of Dental Sciences and Research, Thiruchengodu-637215, India; 5Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; 6Department of Research, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; 7Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; 8Department of Biochemistry and Department of Clinical Skills & Simulation, Department of Research, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123

 

Email

Dr. Jayaraman Selvaraj - Email: jselvaendo@gmail.com;

 

Article Type

Research Article

 

Date

Received December 29, 2020; Revised January 26, 2021; Accepted January 29, 2021, Published January 31, 2021

 

Abstract

It is of interest to document the moelcular docking analysis of SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) with compounds from Plectranthus amboinicus. Hence, we report the binding features of rutin, Luteolin, Salvianolic acid A, Rosmarinic acid and p-Coumaric acid with the target protein SARS-CoV-2 linked RNA dependent RNA polymerase (RdRp) for further consideration.

 

Keywords

SARS-CoV-2, RdRp, Plectranthus amboinicus, molecular docking

 

Citation

Selvaraj et al. 17(1): Bioinformation 167-170 (2021)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.