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Title

Molecular modeling of cornulin (CRNN) for docking with phytocompounds from Justicia adhatoda L.

 

Authors

Jayaraman Selvaraj1,*, Shazia Fathima JH2, Venkatacalam Sivabalan3, Umapathy Vidhya Rekha4, Rajagopal Ponnulakshmi5, Veeraraghavan Vishnupriya1, Malathi Kullappan6, Radhika Nalinakumari Sreekandan7, Surapaneni Krishna Mohan8, Periyasamy Vijayalakshmi8

 

Affiliation

1Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 2Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India; 3Department of Biochemistry, KSR Institute of Dental Sciences and Research, Thiruchengodu-637215, India; 4Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; 5Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; 6Department of Research, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; 7Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India;8Department of Biochemistry and Department of Clinical Skills & Simulation, Department of Research, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123;

 

Email

Dr. Jayaraman Selvaraj - E-mail:jselvaendo@gmail.com

 

Article Type

Research Article

 

Date

Received December 29, 2020; Revised December 31, 2020; Accepted January 26, 2020, Published January 31, 2021

 

Abstract

Cornulin (CRNN) is linked with tumour progression. Therefore, it is of interest to document data on the molecular modeling of cornulin (CRNN) for docking with phytocompounds (Pyrazinamide, Anisotine, Vasicinone, Vasicoline) from Justicia adhatoda L. Thus, we document the optimal binding features of these compounds with the cornulin model for further consideration.

 

Keywords

Oral Squamous Cell Carcinoma, cornulin, molecular modeling, and molecular docking.

 

Citation

Selvaraj et al. Bioinformation 17(1): 200-205 (2021)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.