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Title

Molecular docking analysis of vascular endothelial growth factor receptor with bioactive molecules from Piper longum as potential anti-cancer agents

Authors

Selvaraj Jayaraman1,*, Vidhya Rekha Umapathy2, Jayamathi Govindaraj3, Keerthidaa Govidaraj4

 

Affiliation

1,*Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 2Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai,Chennai-600 100, India; 3Department of Biochemistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India; 4MGM Health Care, Nelson Manickam Road, Chennai- 600029, India;

 

Email

Dr. Selvaraj Jayaraman - Email: jselvaendo@gmail.com

 

Article Type

Research Article

 

Date

Received December 29, 2020; Revised January 15, 2020; Accepted January 26, 2020, Published January 31, 2021

 

Abstract

It is known that vascular endothelial growth factor receptor (VGFR) is linked with cancer. Therefore, it is of interest to document the molecular binding features of bioactive molecules from Piper longum as potential anti-cancer agents with VGFR2 for further consideration. Thus, we document the binding features of four compounds (sesamin, fargesin, longamide and piperlonguminine) with VGFR2 for further consideration in drug discovery.

 

Keywords

VEGFR; Piper longum; lung cancer; molecular docking

 

Citation

Selvaraj et al. Bioinformation 17(1): 223-228 (2021)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.