Molecular docking analysis of stevioside with AKT and PPARγ

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Title	Molecular docking analysis of stevioside with AKT and PPARγ
Authors	Abilasha Deenadayalan^1,2,S Vijayalakshmi^1,*, CS Janaki³ & Selvaraj Jayaraman⁴
Affiliation	¹Department of Anatomy, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Chennai-602105, India; ²Department of Anatomy, Asan Memorial Dental College and Hospitals, Asan Nagar, Chengalpattu, Chennai-602 105, India; ³Department of Anatomy, Bharath Medical College and Hospital, Selaiyur, Chennai-600 073, India; ⁴Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai- 600 077, India;
Email	Dr. S. Vijayalakshmi - Email: abipriya.papu@gmail.com
Article Type	Research Article
Date	Received January 10, 2020; Revised January 30, 2020; Accepted January 31, 2020, Published January 31, 2021
Abstract	Stevioside is a diterpenoid glycoside consisting of an aglycone (steviol) and three glucose molecules. It is commonly used as an anti-hyperglycemic food because of its non-caloric property. Therefore, it is of interest to document the interactions of stevioside with AKT & PPAR-γ proteins using Autodock Vina PyRx docking techniques. Results of the docking studies indicate that stevioside had more than two hydrogen bond interactions with the AKT and PPAR γ protein for further consideration.
Keywords	Diabetes, AKT & PPAR gamma, stevioside, molecular docking
Citation	Deenadayalan et al. Bioinformation 17(1): 283-288 (2021)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.