Title

Antioxidant, antimicrobial and cytotoxicity potential of n-hexane extract of Cayratia trifolia L

Authors

Meganathan Bhuvaneswari¹, Palanisamy Chella Perumal² & Panagal Mani^1,*

Affiliation

¹Department of Biotechnology, Annai College of Arts and Science, Kovilacheri, Tamil Nadu 612503, India; ²State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China

Email

Panagal Mani - Email: mani.panagal@yahoo.com; Phone: +91 9976918228; Corresponding author*

Article Type

Research Article

Date

Received February 28, 2021; Revised March 30, 2021; Accepted March 30, 2021, Published March 31, 2021

It is of interest to analyze the antioxidant, antimicrobial and cytotoxicity activity of n-hexane extract of Cayratia trifolia L. (C. trifolia). The antimicrobial activity of n-hexane extract of C. trifolia was determined using disc diffusion method against six selected pathogenic microorganisms. The cytotoxicity potential of n-hexane plant extract was also studied against A2780 cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Results, n-hexane extract of C. trifolia possess significant antioxidant activity with significant IC50 values in radical scavenging assays. In antimicrobial studies, the maximum zone of inhibition was found in the range of 19.0 ± 0.1 to 22.0 ± 0.1 mm. In MTT assay, inhibition of cell growth with minimal IC50 values of 46.25±0.42μg/mL against A2780 cell lines was observed. Thus, n-hexane extract of C. trifolia is a possible antioxidant, antimicrobial and cytotoxicity agent.

Keywords

Cayratia trifolia; n-hexane extract; Antioxidant activity; Antimicrobial activity; Cytotoxicity activity

Citation

Bhuvaneswari et al. Bioinformation 17(3): 452-459 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.